Phenylpiperazinotetrahydronaphthols and derivatives

Details Phenylpiperazinotetrahydronaphthols and derivatives Phenylpiperazinotetrahydronaphthols and derivatives

C - Chemistry, Metallurgy

07

D

260/267.2

C07D 295/04 (2006.01)

Patent

CA 1088537

Abstract New compounds and the pharmaceutically acceptable acid addition salts thereof, which are useful hypotensive agents, have the structure Image wherein R1 is hydrogen, Image wherein X is alkyl of 1 to 12 carbon atoms or aryl, or Image wherein Y is lower alkyl or aryl; R2 is hydrogen, halogen, lower alkyl, hydroxy, alkoxy or Image ; R3 is hydrogen, halogen, lower alkyl, alkoxy alkyl- thio, trifluoromethyl or nitro; and n is 1, 2 or 3 wherein the terms lower alkyl, alkoxy and alkylthio refer to groups having 1 to 4 carbon atoms and the term aryl refers to phenyl or phenyl monosubstituted with lower alkyl, alkoxy or halogen.

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