C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/489, 260/645
C07C 43/18 (2006.01) C07C 45/30 (2006.01) C07C 45/59 (2006.01) C07C 45/66 (2006.01) C07C 45/82 (2006.01) C07C 47/277 (2006.01) C07C 49/747 (2006.01) C07C 49/753 (2006.01) C07C 69/12 (2006.01) C07D 307/38 (2006.01) C07D 317/16 (2006.01) C07D 317/20 (2006.01) C07D 317/22 (2006.01) C07F 7/18 (2006.01) C07J 1/00 (2006.01) C07J 13/00 (2006.01) C07J 51/00 (2006.01) C07J 71/00 (2006.01)
Patent
CA 1112658
ABSTRACT OF THE DISCLOSURE Novel cyclisation substrates are disclosed in the formula Image (III) wherein: (a) R1 is H or alkyl of one to four carbon atoms; (b) R2 is H or alkyl of one to four carbon atoms, with the proviso that R1 is H when R2 is alkyl, and with the proviso that R2 is H when R1 is alkyl; (c) R3 is a leaving group selected from the group con- sisting of hydroxy, alkoxy of one to four carbons, alkoxyalkoxy of two to four carbons, acyloxy of one to about seven carbons, and trialkylsilyloxy of less than fifteen carbons; (d) R4 is hydrocarbyl of one to four carbon atoms, a hydrocarbyl of one to two carbon atoms substituted by halogen or alkoxy of one to two carbons, or alkoxy of one to four carbon atoms; and (e) R5 and R5' each are H, OH, alkyl, trialkylsilyloxy, or an esterified or etherified hydroxy-group of about one to ten carbon atoms, leading to novel and biologically active compounds of the following formulae: Image Image (IV) (V) "para" "ortho" having R1 through R5' as defined above, with R6 being alkyl of from one to about four carbon atoms, among which are intermediates for preparing well known biologically active 7.alpha.-substituted steroids, such as 7.alpha.-methyl-oestrone; 7.alpha.-methoxy-oestra- diol and the like.
297553
Groen Marinus B.
Zeelen Filippus J.
Akzona Incorporated
Swabey Ogilvy Renault
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