Piperazinyl and homopiperazinyl quinazolines

Details Piperazinyl and homopiperazinyl quinazolines Piperazinyl and homopiperazinyl quinazolines

C - Chemistry, Metallurgy

07

D

260/253, 260/240

C07D 405/14 (2006.01) C07D 239/95 (2006.01) C07D 319/20 (2006.01)

Patent

CA 1088059

Abstract The invention relates to new quinazoline derivatives of the formula Image (I) wherein (R)n represents 6,7-di(lower alkoxy) or 6,7,8-tri(lower alkoxy); m is 1 or 2; X represents -CHR1- or -CH2CH2-; each R1, which may be the same or different, represents hydrogen or lower alkyl; and R2 and R3, which may be the same or different, each represent hydrogen, lower alkyl, lower alkoxy, halogen, lower alkanoyl, lower alkoxycarbonyl or a group of the formula -CONR4R5 or -SO2NR4R5 wherein R4 and R5, which may be the same or different, each represent hydrogen or lower alkyl; and the pharmaceutically acceptable acid addition salts thereof. Two processes for preparing these derivatives are also described. The new quinazolines are useful as regulators of the cardio- vascular system, in particular for the treatment of hypertension.

314027

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