Penetrating topical pharmaceutical compositions

Details Penetrating topical pharmaceutical compositions Penetrating topical pharmaceutical compositions

A - Human Necessities

61

K

167/159

A61K 47/00 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01)

Patent

CA 1165240

PENETRATING TOPICAL PHARMACEUTICAL COMPOSITIONS Eugene R. Cooper Maurice E. Loomans Richard R. Wickett Abstract A large group of lipophilic, pharmacologically active compounds can be effectively delivered across intact skin by applying them topically in a binary, penetration-enhancing vehicle containing (1) a C3-C4 diol, diol ester, or diol ether and (2) a cell envelope- disordering compound. This vehicle provides surprising enhancement of skin penetration for the pharmacological active, compared to either component alone.

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