A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/223
A61K 31/495 (2006.01) C07D 295/15 (2006.01)
Patent
CA 1095832
TITLE PHARMACEUTICAL COMPOSITIONS CONTAINING PIPERAZINYL ACYLHYDROXAMIC ACID DERIVATIVES INVENTORS Ronald T. Coutts David F. Biggs Frank W. Wandelmaier Frank D. Semaka ABSTRACT OF THE DISCLOSURE Compounds of the following general formula have been found to have biological activity and are useful in pharmaceutical compositions: Image I where m = 0, 1 or 2 R = alkylene straight or branched chain of up to 3 carbon atoms, and X when present is a salt-forming acid. Typical compounds are 2-methyl-3-{1-(4-phenyl) piperazinyl} propionohydroxamic acid monohydrochloride and {1-(4-phenethyl) piperazinyl} acetohydroxamic acid dihydrochloride. These compounds have been found to have at least one of anti- inflammatory, anti-anaphylactic and anti-depressant activity.
315010
Biggs David F.
Coutts Ronald T.
Semaka Frank D.
Wandelmaier Frank W.
Canadian Patents And Development Limited
Thomson Alan A.
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