Prostanoic acid derivatives and process for producing same

Details Prostanoic acid derivatives and process for producing same Prostanoic acid derivatives and process for producing same

C - Chemistry, Metallurgy

07

D

260/235.01

C07D 317/30 (2006.01) C07C 405/00 (2006.01)

Patent

CA 1105013

ABSTRACT OF THE DISCLOSURE A prostanoic acid derivative of the formula Image (I), which is luteolytic is produced, for example, from a ketone of the formula Image (II) , by ketalizing the ketone, reducing the ketal thus produced with a diisobutyl-aluminium hydride, and reacting the resulting hemi- acetal with a Wittig reagent of the formula PH3P=CH-(CH2)3-COOR, In the above formulae, R1 represents a hydrogen atom, a straight or branched alkyl group containing 1-10 carbon atoms, a substituted or unsubstituted aryl group or a -CH2-U-V- group, in which U is a direct bond, a carbonyl or carbonyloxy group and V is a phenyl ring substituted by one or more phenyl groups, alkoxy groups containing 1-2 carbon atoms, or halogen atoms, preferably bromine atoms; R2 and R3 are different and represent a hydroxyl group or a hydrogen atom, or R2 and R3 together represent an oxygen atom; A represents -CH2-CH2- or a trans -CH=CH-group; B represents a -CH2-CH2- or a cis-CH=CH-group; D and E together represent a direct bond or D represents a straight chained or branched alkylene group containing 1-5 carbon atoms, and E represents an oxygen or sulphur atom; R4 represents a straight chained or branched alkyl group containing 1-10 carbon atoms, a straight chained or branched alkyl group containing 1-5 carbon atoms substituted by optionally substituted aryl, an optionally substituted aryl group or a benzodioxol-2-yl group; and Image represents Image or Image , when R2 and R3 are different and represent a hydroxyl group or a hydrogen atom, or Image represents Image or -CH=CH-, when R2 and R3 together represent an oxygen atom; Ac represents an aliphatic or aromatic acyl group; and Ph represents a phenyl group.

231348

Affiliated with

Also associated with

Rating

Prostanoic acid derivatives and process for producing same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Prostanoic acid derivatives and process for producing same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Prostanoic acid derivatives and process for producing same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-671574