Steroidal 16.beta.-alkyl-¬16.alpha.,17-b|naphthalenes

Details Steroidal 16.beta.-alkyl-¬16.alpha.,17-b|naphthalenes Steroidal 16.beta.-alkyl-¬16.alpha.,17-b|naphthalenes

C - Chemistry, Metallurgy

07

J

260/58

C07J 5/00 (2006.01) C07J 7/00 (2006.01) C07J 13/00 (2006.01) C07J 53/00 (2006.01) C07J 71/00 (2006.01)

Patent

CA 1088516

Abstract Novel steroids, which are useful topical and systemic antiinflammatory agents, have the structure Image or the 1,2-dehydro derivatives thereof, wherein R1 is chlorine, fluorine or hydroxy and R'1 is hydrogen, or R1 and R'1 together are =O; R2 is hydrogen or halogen; R3 is hydrogen, methyl or fluorine; R4 is hydrogen, hydroxy, alkyl-?-O-, aryl-?-O- or halogen; R5 and R6 are the same or different and are hydrogen, alkyl, alkoxy, carboalkoxy, formyl, alkyl-?-, alkyl-?-O-, hydroxy, halogen, phenyl or cyano, with the proviso that when R5 and R6 are different, one of R5 and R6 is hydrogen; and R7 and R8 are the same or different and are hydrogen or alkyl.

265279

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