3-hydroxy-1,4-benzodiazepine-2-ones and process for the...

Details 3-hydroxy-1,4-benzodiazepine-2-ones and process for the... 3-hydroxy-1,4-benzodiazepine-2-ones and process for the...

C - Chemistry, Metallurgy

07

D

260/240.5

C07D 243/24 (2006.01)

Patent

CA 1113464

ABSTRACT OF THE DISCLOSURE The invention provides 3-hydroxy-1,4-benzodiazepine- 2-ones which have the structural formula (I) Image in which R is the methoxy or nitrile group, R1 is hydrogen, halogen, trifluoromethyl or nitro and R2 is hydrogen or halogen with the proviso that R is different from methoxy, when R2 is o-halogen. The compounds have marked sedative and sleep prolonging activity when evaluated in standard pharmacological procedures.

342046

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