Process for the preparation of .beta.-lactam antibiotics

Details Process for the preparation of .beta.-lactam antibiotics Process for the preparation of .beta.-lactam antibiotics

C - Chemistry, Metallurgy

07

D

260/110, 260/299

C07D 498/04 (2006.01) C07D 499/16 (2006.01)

Patent

CA 1157850

ABSTRACT The present invention provides a process for the preparation of a fused bicyclic .beta.-lactam containing compound having an optionally salified free carboxylic acid group which process comprises the reaction of an ester of the formula (I): Image (I) with halide ion; wherein R is the residue of the fused bicyclic .beta.-lactam containing compound, R1 is an alkyl group of 1-6 carbon atoms optionally substituted by an alkoxy group of 1-4 carbon atoms or is an optionally substituted phenyl group or an alkyl group of 1-4 carbon atoms substituted by an optionally substituted phenyl group; and R2 is a hydrogen atom or an alkyl group of 1-4 carbon atoms or is joined to R2 to form part of a 5- or 6- membered carbocyclic or heterocyclic ring.

379436

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