4-piperidinylalkyl-3,3-diphenyl-2-pyrrolidinones

C - Chemistry – Metallurgy – 07 – D

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260/278.9

C07D 401/06 (2006.01) C07D 207/26 (2006.01) C07D 211/32 (2006.01)

Patent

CA 1068707

HETEROCYCLIC ANALGETIC AND ANTIDIARRHEAL COMPOUNDS ABSTRACT OF THE DISCLOSURE 1-R-4-(omega-substituted alkyl)-3,3-diphenyl-2- pyrrolidinones of the formula Image wherein R is hydrogen, lower alkyl or benzyl, R2 is hydrogen, chloro, bromo, fluoro, trifluoromethyl or lower alkoxy, R2 is hydrogen, chloro, bromo, or fluoro, A is hydroxy, lower-alkyl- carbonyloxy or lower-alkoxycarbonyl and n is 1, 2 or 3 having analgetic and antidiarrheal activity are disclosed, The pharmaceutically acceptable acid addition salts of the bases are within the scope of the present invention.

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