Method for increasing shelf-life of a serum bilirubin...

A - Human Necessities – 61 – K

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A61K 35/16 (2006.01) G01N 33/96 (2006.01) G01N 33/72 (2006.01)

Patent

CA 1106760

417D-184A Can. Abstract of the Disclosure A stable blood serum bilirubin reference composition characterized in that the composition (1) furher comprises a sulfhydryl compound in an amount sufficient to enhance the sta- bility of the bilirubin or (2) possesses a pH of from about 8.3 to about 9.5 and further comprises a sulfhydryl compound in an amount to further enhance the stability of the bilirubin or (3) possesses a pH of from about 8.2 to about 9.2 and further com- prises (a) a sulfhydryl compound in an amount sufficient to enhance the stability of the bilirubin and (b) a chelating agent in an amount sufficient to bind all the metals present in the blood serum moiety of the composition. These blood serum bili- rubin compositions when stored in a gas impervious vial under an inert atmosphere have an excellent shelf life.

331883

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