Oxazole, isoxazole, thiazole and isothiazole amides

Details Oxazole, isoxazole, thiazole and isothiazole amides Oxazole, isoxazole, thiazole and isothiazole amides

C - Chemistry, Metallurgy

07

D

260/253

C07D 413/06 (2006.01) C07D 239/95 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 417/14 (2006.01)

Patent

CA 1081228

ABSTRACT OF THE DISCLOSURE This invention relates to compounds having the formula Image wherein Z is a substituted or unsubstituted oxazole, isoxazole, thiazole, isothiazole or alkylthio substituted 1,3,4-oxadiazole group and non-toxic pharmaceutically acceptable acid addition salts thereof, and to new nitrogenous containing heterocyclic carbonyl piperazinyl quinazolines which are potent antihypertensive drugs having generally less a-adrenergic blocking activity than does 2-[4-(2-furoyl)- piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline which is a known potent antihypertensive drug; and, to processes for their preparation.

271839

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