C - Chemistry – Metallurgy – 08 – L
Patent
C - Chemistry, Metallurgy
08
L
167/160, 167/170
C08L 89/06 (2006.01) A61K 9/70 (2006.01) A61L 15/32 (2006.01) A61L 15/44 (2006.01) A61L 26/00 (2006.01)
Patent
CA 1147726
ABSTRACT Macromolecular reconstituted collagen is prepared by treat- ing natural insoluble collagen with an aqueous solution comprised of an alkali sulfate salt and an alkali metal hydroxide for at least 48 hours to saponify fats suspended within the natural insoluble collagen. The fat free collagen is then treated with an aqueous solution comprised of an alkalie metal sulfate for at least four hours to stabilize the interfibular bonds between individual polypeptide chains. The collagen is then dis- solved in an aqueous acid solution and frozen at a rate of -20°C/hour. The frozen collagen is vacuum dried at 10-3 to 10-5 torr for at least 16 hours to produce a biologically active collagen article. Various bio- logically active materials may be added to the aqueous acid solution prior to freezing. The collagen product may then be implanted into an animal or the like and the medication slowly released. The article can remain within the biological system and it will slowly dissolve due to enzymatic digestion and through other biological processes.
359671
Seton Company
Smart & Biggar
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