Triazoles

Details Triazoles Triazoles

C - Chemistry, Metallurgy

07

D

260/313.3

C07D 249/12 (2006.01) C07C 57/03 (2006.01)

Patent

CA 1097660

ABSTRACT OF THE DISCLOSURE A compound of formula (I): Image (I) wherein; n is 1 to 5 Y is-CH2-CH2 or -CH=CH-; R1 is hydrogen or CO2R1 represents an ester group in which the R1 moiety contains from 1-12 carbon atoms; R2 is hydrogen, C1-4 alkyl, or phenyl; R3 is hydroxy or protected hydroxy; R4 is hydrogen, C1-0 alkyl, C3-8 cycloalkyl, C3-8 cycloalkyl-C1-6 alkyl, phenyl, phenyl -C1-6 alkyl, naphthyl, naphthyl C1-6 alkyl, any of which phenyl moieties or naph- thyl moieties may be substituted by one or more halogen, trifluoromethyl, C1-6 alkyl, hydroxy, C1-6 alkoxy, phenyl C1-6 alkoxy or nitro groups; R5 is hydrogen, C1-6 alkyl, C5-8 cycloalkyl, phenyl, phenyl- C1-6 alkyl or phenyl C3-6 cycloalkyl, any of which phenyl moieties may be substituted by one or more halogen, tri- fluoromethyl, C1-6 alkyl, C1-6 alkoxy or nitro groups, or R2 and R4 taken with the carbon atom to which they are joined represent a C5-8 cycloalkyl group, and salts thereof; has useful pharmacological activity.

293240

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