Method for production of kanamycin c and its derivatives

Details Method for production of kanamycin c and its derivatives Method for production of kanamycin c and its derivatives

C - Chemistry, Metallurgy

07

H

260/230.5

C07H 15/22 (2006.01) C07H 15/236 (2006.01)

Patent

CA 1081692

A METHOD FOR PRODUCTION OF KANAMYCIN C AND ITS DERIVATIVES ABSTRACT OF THE DISCLOSURE Kanamycin C, 3'-deoxykanamycin C and 3'4'- dideoxykanamycin C are obtained by a new process comprising treating the primary 6'-amino group of a tetra-N-protected derivative of kanamycin B, 3'- deoxykanamycin B and 3',4'-dideoxykanamycin B with a nitrite to convert said amino group into hydroxyl group and then removing the protective groups. 3'- Deoxykanamycin C and 3',4'-dideoxykanamycin C are new semi-synthetic aminoglycosidic antibiotics. - 1 -

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