Thieno (2,3-c) pyridine derivatives

Details Thieno (2,3-c) pyridine derivatives Thieno (2,3-c) pyridine derivatives

C - Chemistry, Metallurgy

07

D

260/276.1

C07D 495/04 (2006.01)

Patent

CA 1078844

IMPROVEMENTS IN OR RELATING TO THIENO[3,2-c]PYRIDINE DERIVATIVES Abstract of the disclosure This invention provides compounds of formula I Image I wherein R1 is (i) hydrogen or alkyl of 1 to 4 carbon atoms, or (ii) chlorine or bromine, in the 2,3 or 7 position, or (iii) fluorine, cyano or COOB, wherein B is alkyl of 1 to 4 carbon atoms, in the 2 or 3 position, R2 is (i) hydrogen or alkyl of 1 to 4 carbon atoms, or (ii) chlorine or bromine, in the 2,3 or 7 position, or (iii) fluorine, in the 2 or 3 position, R3 is hydrogen or a group -COR4, wherein - 2 - R4 is alkyl of 1 to 17 carbon atoms, phenyl, phenyl monosubstituted by nitro, phenyl mono- or disubstituted by alkyl of 1 to 4 carbon atoms or halogen with an atomic number of 9 to 35, phenyl mono-, di- or trisubstituted by alkoxy of 1 to 4 carbon atoms, or a group D-COOH, wherein D is ethylene or trimethylene, and R is phenylalkyl of 8 to 10 carbon atoms, phenyl- alkyl of 8 to 10 carbon atoms monosubstituted in the phenyl radical by alkyl of 1 to 4 car- bon atoms, alkoxy of 1 to 4 carbon atoms or halogen with an atomic number of 9 to 35, or phenylalkyl of 8 to 10 carbon atoms disubsti- tuted in the phenyl radical by alkoxy of 1 to 4 carbon atoms, the phenyl ring of each of the phe- nylalkyl radicals being separated by at least 2 carbon atoms from the nitrogen atom to which R is bound and, when R3 is a group -COR4, R alternatively is alkyl of 3 to 7 car- bon atoms, cycloalkyl of 3 to 7 carbon atoms, cycloalkyl of 3 to 7 carbon atoms monosubsti- tuted by alkyl of 1 to 4 carbon atoms, .alpha.-dial- kylpropinyl of 5 to 9 carbon atoms, .alpha.-dialkyl- allyl of 5 to 9 carbon atoms, or phenoxyalkyl of 8 to 11 carbon atoms, the oxygen atom of the phenoxyalkyl radical being separated by at least two carbon atoms from the nitrogen atom to which R is bound, - 3 - with the general proviso that, when R1 is cyano or COOB, R2 is other than fluorine, chlorine or bromine, in the 2 or 3 position, useful in the treatment of heart diseases, hyper- lipoidemia and hyperglycemia

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