Anti-inflammatory combination having reduced ulcerogenicity

Details Anti-inflammatory combination having reduced ulcerogenicity Anti-inflammatory combination having reduced ulcerogenicity

A - Human Necessities

61

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167/240

A61K 31/405 (2006.01) A61K 31/105 (2006.01) A61K 31/165 (2006.01) A61K 31/19 (2006.01) A61K 31/235 (2006.01) A61K 31/40 (2006.01) A61K 31/42 (2006.01) A61K 31/44 (2006.01) C07C 57/58 (2006.01) C07C 59/64 (2006.01) C07C 65/05 (2006.01) C07D 209/28 (2006.01)

Patent

CA 1124648

TITLE OF THE INVENTION IMPROVED ANTI-INFLAMMATORY COMBINATION HAVING REDUCED ULCEROGENICITY ABSTRACT OF THE DISCLOSURE A novel drug combination for more effective treatment of pain, fever, and inflammation with reduced ulcerogenicity comprising (a) l-(p-chlorobenzoyl)-5- methoxy-2-methylindole-3-acetic acid (indomethacin), and (b) a member selected from phenyl benzoic acid compounds, especially 2-hydroxy-5-(2', 4'-difluorophenyl)benzoic acid (diflunisal), wherein the molar ratio of (b) to (a) is from 0.5 to 1.0 to 15.0 to 1Ø

348660

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