Peptides having ubiquitin-like activity

Details Peptides having ubiquitin-like activity Peptides having ubiquitin-like activity

C - Chemistry, Metallurgy

07

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530/5.04, 530/7.

C07K 5/072 (2006.01) C07K 5/06 (2006.01) C07K 5/083 (2006.01) C07K 5/103 (2006.01) C07K 7/06 (2006.01) C07K 14/66 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1146166

ORTH 331 ABSTRACT PEPTIDES HAVING UBIQUITIN-LIKE ACTIVITY Peptides of the following formula: A-B wherein A is a member selected from the group consisting of deamino-GLN, GLN, and (SAR)n-GLN; n is an integer from 1 to 4; and B is a member selected from the group consisting of LYS-OH, LYS-NH2, decarboxy-LYS, Image , LYS-SAR-OH and LYS-SAR-NH2, have signifi- cantly increased ubiquitin-like activity. Also provided are therapeutic compositions and methods for use thereof.

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