C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/238, 260/271
C07D 471/04 (2006.01) C07D 455/02 (2006.01) C07D 455/06 (2006.01)
Patent
CA 1083145
ABSTRACT Compounds of the formula (r), and their pharmaceitically acceptable salts: Image (I) wherein: R1 is a C1-6 alkoxy group, R2 and R3 are the same or different and are hydrogen, halogen, CF3, hydroxy, C1-6 alkoxy, C2-7 acyl, amino, amino substituted by one or two C1-6 alkyl groups, C2-7 acyl amino, aminocarbonyl or aminosulphone optionally substituted by one or two C1-6 alkyl groups, C1-6 alkylsulphone or nitro group, X is either a nitrogen atom, in which case m + n is 3 to 5, m is 2 to 4, n is 1 to 3, or X in CH in which case m + n is 2 to 5, m is 1 to 5, and n is 0 to 4; p is 0 to 3; R4 is hydrogen, C1-6 alkyl, phenyl or phenyl-C1-6 alkyl, either of which phenyl moiety may be substituted by C1-6 alkyl, C1-6 alkoxy, CF3 or halogen, and R5 is hydrogen, or R4 and R5 are attached to two adjacent carbon atoms and form together with these two carbon atoms a fused benzene ring, which benzene ring may be substituted by C1-6 alkyl, C1-6 alkoxy, CF3 or halogen; have useful pharmaceutical activity. The compounds may be used for treatment of disorders of the gastro-intestinal function and/or for treatment of emesis. In addition, the compounds potentiate the effect of conventional analgesics in migraine treatment when administered concurrently therewith.
288777
Hadley Michael S.
Watts Eric A.
Beecham Group Limited
Borden Ladner Gervais Llp
LandOfFree
Quinolizidinyl benzamide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Quinolizidinyl benzamide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Quinolizidinyl benzamide derivatives will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-856656