Isoindole derivatives

Details Isoindole derivatives Isoindole derivatives

C - Chemistry, Metallurgy

07

D

260/321, 260/385

C07D 209/44 (2006.01) C07D 243/24 (2006.01) C07D 307/87 (2006.01)

Patent

CA 1070698

ABSTRACT Isoindole derivatives of the general formula Image I , whereln A represents an alkylene group containing 2-10 carbon atoms, Z represents the group -OR or Image , R represents an alkyl, cycloalkyl, cycloalkylalkyl, alkoxy- alkyl, allyl or aralkyl group, R1, R2, R3 and R4 each independently represent a hydrogen or halogen atom or an alkyl, alkoxy or trifluoromethyl group and R5 and R6 each independently represent a hydrogen atom or an alkyl, cycloalkyl, cycloalkyl- alkyl, hydroxyalkyl, alkoxyalkyl, aryl or aralkyl group or R5 and R6 together represent the group -(CH2)n-, in which n stands for an integer of 2-7, or R5 and R6 together with the nitrogen atom to which they are attached reprecent a 5-membered or 6-membered heterocyclic ring containing an oxygen atom or a further nitrogen atom which may be substituted by an alkyl or hydroxyalkyl group, and R7 and R8 each independently represent a hydrogen atom or an alkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl or aralkyl group with the proviso that at least one of R7 and R8 represents other than a hydrogen atom, and pharmaceutically acceptable acid addition salts thereof, having anorectic properties and a process for the manufacture thereof.

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