Steroids

C - Chemistry – Metallurgy – 07 – J

Patent

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260/5

C07J 61/00 (2006.01)

Patent

CA 1101409

Abstract of the Disclosure The steroids of the present invention are A-nor-androsta- 3(5),16-dien-2-one derivatives of the general formula- I Image wherein R1 and R2 are the same or different and each represents a hydrogen atom or a methyl group, the dotted line in the 6-7 position indicates the optional presence of an additional double bond and the wavy line in the 1 position indicates that the substituent R1 is either in .alpha.- or .beta.-configuration. These steroids have strong topical anti-androgenic activity and may be used in the treatment of various dermatological disorders, including hirsutism, acne, seborrhoea, alopecia androgenetica and baldness. Of outstanding interest is the compound A-nor- androsta-3(5),16-dien-2-one.

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