Neuromuscular blocking tetrahydroisoquinolinium salts

Details Neuromuscular blocking tetrahydroisoquinolinium salts Neuromuscular blocking tetrahydroisoquinolinium salts

C - Chemistry, Metallurgy

07

D

260/277.3

C07D 217/20 (2006.01)

Patent

CA 1153380

HP/78 Abstract Neuromuscular Blocking Agents This invention provides the neuromuscular blocking agents of formula (I): Image .2X- I where B and C are each a group of formula (II) and are meta or para to one another: Image II wherein D is CH2CH2 or CH=CH (preferably trans); Y is alkyl of 1-4 carbon atoms (methyl, ethyl, propyl or butyl); E and Q are H or OCH3; X- is an anion, preferably pharmaceutically acceptable; and the substituted benzyl and substituted propyl groups are in a trans relationship relative to each other in the nitrogen-containing ring. CDLSP2-G/1/tc HP/78 Methods for preparing the compounds, pharmaceutical formulations containing the compounds, and their use are also described. CDLSP2-G/2/tc

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