Hydroxyaminomethyl derivatives of benzoyl di-substituted...

Details Hydroxyaminomethyl derivatives of benzoyl di-substituted... Hydroxyaminomethyl derivatives of benzoyl di-substituted...

C - Chemistry, Metallurgy

07

D

260/385, 260/472

C07D 295/14 (2006.01) C07C 59/90 (2006.01) C07D 295/112 (2006.01)

Patent

CA 1149803

Abstract of the Disclosure Described are compounds of the formula Image wherein R1 is Image wherein R5 and R6 are hydrogen, loweralkyl or together are alkylene of 4 or 5 carbon atoms, R2 is hydrogen, halo, haloloweralkyl, loweralkyl, loweralkoxy, loweralkylthio or Image wherein R5 and R6 are as previously defined, R3 is hydroxy, alkoxy, branched alkoxy, adamantyloxy, morpholino, amino or amino substituted by loweralkyl or alkylene of 4 or 5 carbon atoms, R4 is hydrogen or loweralkyl, and X1 and X2 are hydrogen, loweralkyl, halo or when substituted on adjacent carbon atoms of the benzene ring form a 1,3-butadienylene linkage, with the proviso that X1 and X2 are not both hydrogen, and pharmaceutically acceptable salts thereof, the compounds are effective as diuretic agents in increasing urinary excretion.

360297

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