Geldanamycin derivatives and antitumor drug

Details Geldanamycin derivatives and antitumor drug Geldanamycin derivatives and antitumor drug

C - Chemistry, Metallurgy

07

D

260/237.1, 260/2

C07D 295/10 (2006.01) C07D 225/06 (2006.01) C07D 491/06 (2006.01)

Patent

CA 1113935

ABSTRACT OF THE DISCLOSURE Geldanamycin derivatives having the following formulae Image (I) wherein R1 represents a saturated alkylamino group which has at least two carbon atoms, an unsaturated alkylamino group, a sub- stituted lower alkylamino group, a cycloalkylamino group, a pyrrolidino group or an aralkylamino group or a methoxy group; R2 represents hydrogen atom, a halogen atom or a lower mono or dialkylamino group; provided that when R1 is methoxy group, R2 is a halogen atom or lower alkylamino group or Image (II) and the Geldanamycin Derivative 8,4-epoxy-Geldanamycin. The compounds are useful as antitumor drugs.

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