C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/311
C07D 263/48 (2006.01)
Patent
CA 1072103
ABSTRACT OF THE DISCLOSURE The invention as disclosed herein provides compounds of formula I: Image (I) wherein Rl and R2 are independently hydrogen, C1-6alkyl, C1-4 hydroxyalkyl, C3-8 cycloalkyl, C3-6 acyloxyalkyl, or a phenyl group optionally substituted with a halogen atom, or with a trifluoromethyl, methyl, methoxy or nitro group; R3 is hydrogen, C1-6 alkyl, C2-6 alkenyl, C3-6 alkoxyalkyl, C3-8 cycloalkyl, C3-8 cycloalkyl-C1-4 alkyl, a phenyl group optionally substituted with a halogen atom, or with a trifluoromethyl,methyl, methoxy or nitro group -C1-4 alkyl, or a phenyl group optionally substituted with a halogen atom, or with a trifluoromethyl, methyl, methoxy or nitro group -C2-4 alkenyl;and R4 represents the group NHR5 or OR5 where R5 is C1-6 alkyl, C3-8 cycloalkyl, C2-4 alkenyl, a phenyl group optionally substituted with a halogen atom, or with a trifluoromethyl, methyl, methoxy or nitro group, C1-6haloalkyl or C7-10 aralkyl, provided that, where R4 represents NHR5, R3 cannot be hydrogen when all of Rl, R2 and R5 are selected from hydrogen, C1-6 alkyl and a phenyl group optionally substituted with a halogen atom, or with a trifluoromethyl, methyl, methoxy or nitro group. The above compounds are useful for the treatment of immediate hypersensitivity diseases such as asthma and in the alleviation of status asthmaticus.
250052
Ross William J.
Todd Alec
Verge John P.
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