Thiaprostaglandine

Details Thiaprostaglandine Thiaprostaglandine

C - Chemistry, Metallurgy

07

C

260/235.01

C07C 405/00 (2006.01) C07D 213/32 (2006.01) C07D 303/04 (2006.01) C07D 303/22 (2006.01) C07D 333/18 (2006.01)

Patent

CA 1072549

ABSTRACT OF THE DISCLOSURE The invention relates to novel 13-thiaprostanoic acid derivatives of Formula I Image I wherein A is -CO- or -CHOH-, B is -CH2-CH2- or -CH=CH-, R1 is H or an alkyl group with 1 to 4 carbon atoms, m is an integer between 0 to 5, n is an integer between 0 to 3, or, when B is -CH=CH-, also 4, 5, 6, 7, 8 or 9. R2 is alkoxy with 1 to 4 carbon atoms, phenory, pyridyl, thienyl, naphthyl. phenyl substituted by F, C1, Br, OH OCH3 or CF3, or phenoxy substituted by F, C1, Br, OH, OCH3, CH3 or CF3, or when B is -CH=CH-, also hydrogen, phenyl or toyl, and B3 is H, methyl or ethyl, and the wavy line (?) designates that these compounds are either .alpha.- or .beta.-positioned; as well, the invention relates to the physiologically accept- able salts of same. The compounds of Formuls I have useful pharmacological properties.

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