Vindesine synthesis

Details Vindesine synthesis Vindesine synthesis

C - Chemistry, Metallurgy

07

D

260/237.3

C07D 519/04 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 1148945

-1- ABSTRACT A process for preparing vindesine which comprises reacting 4-desacetyl VLB C-3 carboxazide with trihydrocarbyl- phosphine (wherein hydrocarbyl is alkyl or phenyl) to form a 4-desacetyl VLB C-3 N-(trihydrocarbylphosphoranyl) carboxamide and then decomposing said acyl iminophosphorane with acid to yield vindesine. Also disclosed is the process for preparing a 4-desacetyl VLB C-3 N-(trihydrocarbylphosphoranyl) carboximide which comprises reacting 4-desacetyl VLB C-3 carboxazide with trihydrocarbylphosphine (wherein hydrocarbyl is alkyl or phenyl). The 4-desacetyl VLB C-3 N-(trihydrocarbylphosphoranyl) carboxi- mide compounds are novel.

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