C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/246, 260/267
C07D 295/00 (2006.01) C07D 295/135 (2006.01) C07D 295/15 (2006.01) C07D 295/182 (2006.01) C07D 295/215 (2006.01)
Patent
CA 1074311
ABSTRACT OF THE DISCLOSURE Novel N-benzylipiperazine derivatives of the general formula Image (I) wherein R1 and R2 are the the same or different and each stands for a hydrogen atom, an alkylcarbonyl group in which the alkyl moiety contains 1 to 3 car- bon atoms or benzoyl; R3 stands for a hydrogen atom, a carbamoyl group, benzoyl an alkylcarbonyl group in which the alkyl moiety contains 1 to 3 carbon atoms and which is unsubstituted or substituted by mercapto or morpholino, or an alkyl group containing from 1 to 6 carbon atoms which is unsubstituted or substituted by hydroxy, phenyl or aminocarbonyl represented by the formula Image wherein each of R4 and R5 is a hydrogen atom, a lower alkyl group having 1 to 3 carbon atoms or a cyclo- hexyl group, or R4 and R5 form a morpholino or piperidino ring together with the nitrogen atom adjacent thereto, and X stands for a halogen atom, and pharmaceutically acceptable acid addition salts thereof. The compounds and salts exhibit respiratory tract fluid secretion stimulatory properties and are useful as medicines such as respiratory tract fluid secretion stimulators.
239892
Ishiguro Toshihiro
Sanno Yasushi
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