Pharmaceutical composition containing xanthine

A - Human Necessities – 61 – K

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A61K 31/52 (2006.01)

Patent

CA 1069439

Pharmaceutical compositions A b s t r a c t A pharmaceutical composition for oral administration in dosage unit form which comprises at least one xanthine derivative selected from a) (w-1)-hydroxyalkyl-dialkylxanthines wherein the (w-1)-hydroxyalkyl group contains 5 or 6 carbon atoms and is in the 1- or 7-position, the alkyl group in the other of the 1- and 7-position contains from 1 to 12 carbon atoms and the alkyl group in the 3-position contains from 1 to 4 carbon atoms, b) (w-1)-oxoalkyl-dimethylxanthines wherein the (w-1)- oxoalkyl group contains 5 or 6 carbon atoms and is in the 1- or 7-position and c) dimethylxanthine derivatives having an additional alkyl group containing from 4 to 12 carbon atoms or a benzyl group in the 1- or 7-postion, and a saliva forming agent, each dosage unit containing at least 300 mg, of xanthine derivative and the weight ratio of xanthine derivative to saliva forming agent is in the range from 1 : 2 to 10 : 1. and a method for its preparation.

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