Process of improving the compatibility of gamma globulins

Details Process of improving the compatibility of gamma globulins Process of improving the compatibility of gamma globulins

A - Human Necessities

61

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167/139

A61K 39/395 (2006.01) A61K 47/32 (2006.01) A61K 47/36 (2006.01) A61K 47/42 (2006.01) C07K 16/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1058075

Abstract A process of improving the intravenous compatibility of gamma globulin precipitated from blood or blood products, wherein the gamma globulin precipitate is resolved in an aqueous solution in which macromolecular substances shield- ing the globulin molecules from each other and displacing them from the solution are present. Such shielding substan- ces are hydroxylethyl starch, gelatine, dextranes, albumin, plyalcohols or polyvinyls. Especially hydroxylethyl starch (HES) in that said aqueous solution from which the gamma globulin is subsequently precipitated, yields good results. The gamma globuline is than re-dissolved, particularly in a physiological normal saline solution.

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