N-phenoxyalkylpiperidine derivatives

Details N-phenoxyalkylpiperidine derivatives N-phenoxyalkylpiperidine derivatives

C - Chemistry, Metallurgy

07

D

260/261, 260/278

C07D 211/36 (2006.01) C07D 211/22 (2006.01) C07D 211/58 (2006.01) C07D 401/10 (2006.01)

Patent

CA 1139759

ABSTRACT The present invention provides N-phenoxyalkyl- piperidine derivatives of the general formula:- Image wherein R1 is a hydrogen atom, an acyl radical or an optionally substituted aryl radical, R2 is a hydroxy- methyl radical, a cyano group, an amidino group, which is optionally substituted by hydroxyl, a 1H-tetrazol-5- yl radical or a -CO-R3 radical, R3 is a hydroxyl group, a lower alkoxy radical or an amino group, which is optionally substituted by a 1H-tetrazol-5-yl radical, X is an imino group or an oxymethyl radical, A is an alkylene radical containing 2 to 4 carbon atoms and B is a valency bond or a 4-hydroxypyrimidin-2,5-diyl radical; and the pharmacologically acceptable salts The present invention also provides a process for the preparation of these compounds, as well as pharmaceutical compositions containing them and the use thereof for the preparation of pharmaceutical compositions with an anti-allergic, anti-oedematous or anti-phlogistic action.

361880

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