A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/237
A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/485 (2006.01) A61K 31/505 (2006.01) A61K 31/52 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07C 17/16 (2006.01) C07D 233/84 (2006.01) C07D 319/20 (2006.01) C07D 521/00 (2006.01)
Patent
CA 1162855
Abstract of the Disclosure Pharmaceutical formulations which comprise an imidazole of formula Image (IA) wherein i) A is a straight or branched alkelene or alkenylene group having 1, 2, 3 or 4 carbon atoms and R is an arylthio, arylalkylthio, aryloxy or arylalkyloxy group, or ii) A is a straight or branched alkylene or alkenylene group having 1 or 2 carbon atoms and R is a 2- pyridyl, l-methylbenzimidazol-2-yl, 2- or 3-indolyl, 1-piperindinyl or l-morpholinyl group, or iii) A is a chemical bond and R is a heterocyclyl or substituted phenyl group, or a pharmaceutically acceptable acid addition of the said imidazole, together with a pharmaceutically acceptable carrier for the imidazole or salt thereof, inhibit TXA2 synthetase in the treatment ofiprophylaxis of thromboembolic disorders and do not produce side effects associated with imidazole, they inhibit platelet aggregation and are capable of disaggregat- ing platelet clumps.
416728
Marcoux & Sher Swabey Mitchell Houle
Wellcome Foundation Limited (the)
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