Process for the preparation of indoloquinolizine derivatives

Details Process for the preparation of indoloquinolizine derivatives Process for the preparation of indoloquinolizine derivatives

C - Chemistry, Metallurgy

07

D

260/272

C07D 455/02 (2006.01) C07D 471/14 (2006.01)

Patent

CA 1074318

Abstract of the Disclosure This invention relates to a compound of the formula I Image I wherein R1 is a hydroxy group, or a straight-chained or branched C2-18 alkoxy group or if R2 is different from ethyl R1 can also stand for methoxy, R2 is a C1-6 alkyl group and X stands for a hydrogen atom in the cis or trans position related to R2, and corresponding pharmaceutically acceptable, salts optical antipodes or isolated cis and trans isomers thereof. On the basis of pharmaceutical investigations the compounds of the present invention possess a considerable haemodynamic activity which can be observed in the field of vasodilatation, in blood pressure decrease and in the change of the pulse rate. This invention also relates to a new process for the preparation of the compounds of formula I by reacting a compound of the formula II Image II wherein R2 stands for an alkyl group containing 1 to 18 carbon atoms or an acid addition salt thereof with an acrylate of the general formula III Image III wherein R3 represents an alkoxy group having 1 to 18, preferably 1 to 6 carbon atoms, - and reducing the compound of the general formula IV Image IV thus obtained.

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