Plasminogen activator-heparin conjugates

Details Plasminogen activator-heparin conjugates Plasminogen activator-heparin conjugates

A - Human Necessities

61

K

167/103.33

A61K 38/49 (2006.01) A61K 47/48 (2006.01) C12N 9/72 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1337796

A pharmaceutical composition is prepared wherein a biologically active conjugated plasminogen activator is selectively conjugated to at least one heparin fragment having a terminal 2,5-anhydro-D-mannose residue which has an aldehyde not involved in intramolecular hemiacetal formation. The resulting conjugate has a prolonged half- life as compared to native tissue plasminogen activator and is able to deliver heparin to the site of clot dis- solution to prevent reocclusion.

607907

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