C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/242.01, 260/
C07D 487/04 (2006.01) C07D 213/50 (2006.01) C07D 233/16 (2006.01) C07D 239/06 (2006.01) C07D 471/14 (2006.01)
Patent
CA 1173831
Abstract of the Disclosure The present invention relates to a process for the manufacture of novel polyazaheterocyclic compounds of the general formula I Image (I), in which Rl and R2 represent, independently of each other, optionally substituted, lower aliphatic hydrocarbon radicals, optionally substituted aryl or heteroaryl each having not more than 2 rings and each being bonded directly or by way of lower alkylene or lower alkenylene, R3 represents hydrogen or lower alkyl, and represents optionally branchad lower alkylene or lower alkenylene having 2 to 4 carbon atoms in 3 direct chain between the adjacent nitrogen atoms, and Zl, Z2. Z3 and Z4 are members of the unsubstituted or substi- tuted sing 3 and represent radicals -CH= carrying the substituents of ring B, if such are present, one of which members can however also be the radical -N=, wherein Rl and R2 do not both repre- sent methyl or both represent ethyl if R3 represents hydrogen and A represents etheny- lene and, at the same time, the ring B is unsubstituted, and their acid addition salts. The compounds of the general formula I possess diuretic and anti-hypertensive activity which is especially pronounced in those compounds of which the radical A has 3 or 4 carbon atoms in a direct chain between the adjacent nitrogen atoms. Compounds of the general formula 1 of which the radical A has 2 carbon atoms in a direct chain between the adjacent nitrogen atoms are especially antidiabetically active.
383782
Frei Jorg
Schweizer Ernst
Fetherstonhaugh & Co.
Novartis Ag
LandOfFree
Process for the manufacture of novel polyazaheterocyclic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for the manufacture of novel polyazaheterocyclic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the manufacture of novel polyazaheterocyclic... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1324889