Human brainiac-5

A - Human Necessities – 61 – K

Patent

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Details

A61K 35/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/705 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/14 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2356548

The present invention relates to novel Brainiac-5 polypeptides which are members of the Brainiac family. In particular, isolated nucleic acid molecules are provided encoding the human Brainiac-5 polypeptides. Brainiac-5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Brainiac-5 activities. Also provided are diagnostic methods for detecting immune and nervous system- related disorders and therapeutic methods for treating, preventing, and/or diagnosing immune and nervous system-related disorders.

La présente invention concerne de nouveaux polypeptides Brainiac-5 qui font partie de la famille des Brainiac. L'invention concerne, en particulier, des molécules d'acide nucléique isolées codant les polypeptides Brainiac-5 humains ; ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison permettant de produire ces derniers ; des procédés de criblage permettant d'identifier des agonistes et des antagonistes des activités de Brainiac-5 ; des procédés de diagnostic permettant de détecter des affections du système immunitaire et du système nerveux et des procédés thérapeutiques permettant de traiter, de prévenir et/ou de diagnostiquer les affections du système immunitaire et du système nerveux.

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