Use of tyrosine kinase inhibitors for treating inflammatory...

Details Use of tyrosine kinase inhibitors for treating inflammatory... Use of tyrosine kinase inhibitors for treating inflammatory...

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/015 (2006.01) A61K 31/095 (2006.01) A61K 31/40 (2006.01) A61K 31/403 (2006.01) A61K 31/404 (2006.01) A61K 31/415 (2006.01) A61K 31/4709 (2006.01) A61K 31/495 (2006.01) A61K 31/498 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/66 (2006.01) A61K 45/06 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2452169

The present invention relates to a method for treating inflammatory diseases such as rheumatoid arthritis (RA), comprising administering a tyrosine kinase inhibitor to a human in need of such treatment, more particularly a non-toxic, selective and potent c-kit inhibitor. Preferably, said inhibitor is unable to promote death of IL-3 dependent cells cultured in presence of IL-3.

L'invention concerne un procédé de traitement de maladies inflammatoires telles que l'arthrite rhumatoïde, qui consiste à administrer un inhibiteur de tyrosine kinase à un humain nécessitant un tel traitement, plus précisément un inhibiteur de la c-kit puissant et sélectif, non toxique. De préférence, ledit inhibiteur ne peut pas favoriser la mort de cellules dépendant de IL-3 cultivées en présence de IL-3.

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