Process for preparing levofloxacin or its hydrate

Details Process for preparing levofloxacin or its hydrate Process for preparing levofloxacin or its hydrate

C - Chemistry, Metallurgy

07

D

C07D 498/06 (2006.01)

Patent

CA 2573129

The present invention provides a process of preparing levofloxacin hemihydrate or monohydrate without impurities, i.e. Impurities B, C, D, E, and F. The process comprises (a) adding crude levofloxacin to a novel mixed solvent, (b) refluxing the mixture obtained in (a) to form a solution, and (c) recovering levofloxacin hemihydrate or monohydrate from the solution obtained in (b).

La présente invention a trait à un procédé de préparation de semi-hydrate ou de monohydrate de lévofloxacine sans impuretés, c'est à dire les impuretés B, C, D, E, et F. Le procédé comprend: (a) l'ajout de lévofloxacine à un nouveau mélange de solvant; (b) l'ébullition au reflux du mélange obtenu en (a) pour former une solution; et (c) la récupération de semi-hydrate ou monohydrate de lévofloxacine à partir de la solution obtenue en (b).

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