C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/13 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2182685
The OX-40 antigen is characterised and claimed together with variants and derivatives thereof. Also described are binding agents for the antigen and the use of these in diagnosis and therapy. Examples of such use include a method for the selective depletion of activated CD4+ T-cells in vivo by using immunotoxins comprising an OX-40 antibody conjugated to a toxic molecule (such as Ricin-A chain). The administration of these specific immunotoxins is used therapeutically to deplete autoimmune reactive CD4+ T-cells which have been implicated in diseases including Multiple Sclerosis, Rheumatoid Arthritis, Sarcoidosis, and Autoimmune Uveitis as well as inflammatory bowel disease and graft-versus-host disease. This type of therapy is also beneficial for eradicating CD4+ T-cell lymphomas and alloreactive CD4+ T-cells involved with a transplantation reaction. The use of the human form of the OX-40 antibody will also help in the early diagnosis of all the diseases mentioned above.
L'invention porte sur l'antigène OX-40, ses variantes, ses dérivés et ses agents de fixation, ainsi que leur emploi diagnostique et thérapeutique. Citons à titre d'exemple un procédé de déplétion sélective des cellules T CD 4?+¿ in vivo à l'aide d'immunotoxines comprenant un anticorps OX-40 conjugué à une molécule toxique ( p. ex. la chaîne ricin-A). On administre ces immunotoxines particulières à des fins thérapeutiques pour épuiser les cellules T CD4?+¿ alloréactives à réaction auto-immunitaire intervenant dans différentes affections telles que la sclérose en plaques, la polyarthrite rhumatoïde, la sarcoïdose, l'uvéïte auto-immune ainsi que les inflammations des intestins et les troubles entre greffon et receveur. Ce type de thérapie vaut également pour l'éradication des lymphomes des cellules T CD4?+¿ et des cellules T CD4?+¿ alloréactives intervenant dans les réactions de transplantation. La forme humaine de l'anticorps OX-40 peut également servir à établir un diagnostic précoce des susdites affections.
Vandenbark Arthur Allen
Weinberg Andrew Dale
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Vandenbark Arthur Allen
Weinberg Andrew Dale
LandOfFree
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