Nucleic acids and corresponding proteins entitled 101p3a11...

Details Nucleic acids and corresponding proteins entitled 101p3a11... Nucleic acids and corresponding proteins entitled 101p3a11...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 38/46 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 16/28 (2006.01) C12N 5/12 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2447564

A novel gene (designated 101P3A11 or PHOR-1) and its encoded, and variants thereof, are described wherein 101P3A11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 101P3A11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 101P3A11 gene or fragment thereof, or its encoded protein, or variants thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 101P3A11 can be used in active or passive immunization.

L'invention porte sur un nouveau gène (dit 101P3A11 ou PHOR-1), sur la protéine correspondante et sur leurs variantes, le 101P3A11 présentant une expression spécifique dans les tissus adultes normaux, et une expression aberrante dans les cancers répertoriés dans la table (I). En conséquence le 101P3A11 constitue une cible pouvant servir pour les diagnostics, les pronostiques, la prophylaxie et la thérapie du cancer. Le gène 101P3A11 ou ses fragments ou la protéine correspondante, ou leurs variantes peuvent servir à provoquer une réponse immunitaire humorale ou cellulaire. Les anticorps ou cellules T réagissant avec le 101P3A11 peuvent servir à des immunisation actives ou passives.

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