Benzopyran class iii antiarrhythmic agents

Details Benzopyran class iii antiarrhythmic agents Benzopyran class iii antiarrhythmic agents

C - Chemistry, Metallurgy

07

D

C07D 405/14 (2006.01) A61K 31/445 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2121833

2121833 9312110 PCTABS00022 The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof; wherein n is 0, 1 or 2; wherein R is H or lower alkyl of 1 to 6 carbon atoms; wherein X is selected from the group consisting of hydrogen, methane sulfonamide, nitro, cyano, imidazolyl, alkoxy of 1 to 6 carbon atoms and hydroxy; and wherein Ar is selected from the group consisting of pyridinyl, tetrahydronaphthalenyl, benzofuranyl, and Ph-CH=CH- and phenyl all optionally substituted by methane sulfonamide, nitro, cyano, or imidazolyl with the proviso that when n is 1, Ar is other then phenyl; pharmaceutical compositions containing these compounds and a method for treating cardiac arrhythmias in mammals by administering the compositions.

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