Novel uses of cephaibols

Details Novel uses of cephaibols Novel uses of cephaibols

A - Human Necessities

61

K

A61K 38/10 (2006.01) A61K 38/08 (2006.01) A61P 25/00 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2487246

The invention relates to the use of compounds of general formula AcPhe-Aib-Aib- Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R, in which R represents Phe-ol or Phe- al and w, x, y, and z have the following meaning: a) w represents Gly or Ala; x represents Aib, and y and z represent Iva; b) w represents Gly; x, y, and z represent Iva; c) w represents Gly; x and z represent Aib, and y represents Iva; d) w represents Gly; x, y, and z represent Aib; or e) w represents Gly; x and y represent Aib, and z represents Iva; or of general formula AcPhe-Iva-Gln- Aib-Ile-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser, in which x represents Hyp or Pro, and the physiologically acceptable salts thereof for producing a medicament having a neurological and/or immunosuppressive effect.

L'invention concerne l'utilisation de composés de formule générale (I): AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R, dans laquelle R représente Phe-ol ou Phe-al, et w, x, y, et z ont la signification suivante: a) w représente Gly ou Ala; x représente Aib, et y et z représentent Iva; b) w représente Gly; x, y et z représentent Iva; c) w représente Gly; x et z représentent Aib et y représente Iva; d) w représente Gly; x, y et z représentent Aib; ou e) w représente Gly; x et y représentent Aib et z représente Iva; ou de formule générale (II): AcPhe-Iva-Gln-Aib-Ile-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser, dans laquelle x représente Hyp ou Pro ; ainsi que l'utilisation de leurs sels physiologiquement tolérables pour la production d'un médicament à effet neurologique et/ou immunosuppresseur.

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