Antagonists of pcsk9

Details Antagonists of pcsk9 Antagonists of pcsk9

C - Chemistry, Metallurgy

07

K

C07K 16/40 (2006.01) A61K 39/395 (2006.01) C12N 15/13 (2006.01) C12Q 1/60 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2667989

Antagonists of human proprotein convertase subtilisin-kexin type 9 ("PCSK9") are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.

L'invention concerne des antagonistes de la proprotéine convertase subtilisine-kexine humaine de type 9 (PCSK9). Les antagonistes décrits sont efficaces pour l'inhibition de la fonction de PCSK9 et constituent donc des antagonistes appropriés pour une utilisation dans le traitement de troubles associés avec l'activité de PCSK9. La présente invention concerne également des acides nucléiques qui codent pour lesdits antagonistes, des vecteurs, des cellules hôtes et des compositions qui comprennent les antagonistes. L'invention concerne également des procédés de préparation d'antagonistes spécifiques à PCSK9, ainsi que des procédés d'utilisation des antagonistes pour l'inhibition ou l'antagonisation de la fonction de PCSK9, qui forment des aspects supplémentaires importants de la présente invention.

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