C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 217/70 (2006.01) A61K 31/135 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) C07C 215/30 (2006.01) C07C 215/68 (2006.01) C07C 225/16 (2006.01) C07C 255/59 (2006.01) C07C 317/32 (2006.01) C07C 323/32 (2006.01) C07D 295/084 (2006.01) C07D 295/092 (2006.01) C07D 333/00 (2006.01)
Patent
CA 2140781
Novel compounds of general formula (I), wherein R1 is selected from alkyl, alkoxy, alkenyloxy, arylalkoxy, alkylthio and alkenylthio; R2 is selected from halogen. hydroxy, alkyl, alkoxy, alkenyloxy, alkylthio, alkenylthio, alkylamino, trifluoromethyl, cyano. nitro, alkylsulfinyl, alkylsulfonyl and acyl; R3 and R4 either independently represent alkyl or alkenyl, or R3 and R4 are interconnected to form a heterocyclic system with the nitrogen atom, optionally containing one or more additional heteroatoms; and physiologically acceptable salts thereof, their use as therapeutical substances, especially as urination controlling agents, their use for preparing a urination controlling medicament, pharmaceutical compositions containing them, and methods for preparing the novel compounds.
Nouveaux composés de formule générale (I), où R1 est choisi parmi les groupes alkyle, alcoxy, alkényloxy, arylalcoxy, alkylthio et alkénylthio; R2 est choisi parmi les atomes d'halogène et les groupes hydroxy, alkyle, alcoxy, alkényloxy, alkylthio, alkénylthio, alkylamino, trifluorométhyle, cyano, nitro, alkylsulfinyle, alkylsulfonyle et acyle; R3 et R4 représentent, indépendamment l'un de l'autre, un alkyle ou un alkényle, ou R3 et R4 combinés à l'atome d'azote auquel ils sont liés forment un système hétérocyclique, contenant facultativement un hétéroatome additionnel ou plus; et les sels physiologiquement acceptables de ces derniers, leur utilisation comme agents thérapeutiques, particulièrement comme agents pour réguler la miction, leur utilisation pour préparer un médicament servant à réguler la miction, les compositions pharmaceutiques contenant ces derniers et les méthodes pour préparer ces nouveaux composés.
Nordh Lennart G.
Persson Gustav L.
Sjogren Bengt C. H.
Willman Nils-Erik
Biovitrum Ab
Kabi Pharmacia Ab
Ridout & Maybee Llp
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