Heterocyclic antiviral compounds

Details Heterocyclic antiviral compounds Heterocyclic antiviral compounds

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/4965 (2006.01) A61K 31/497 (2006.01) A61K 31/50 (2006.01) A61K 31/513 (2006.01) A61K 31/53 (2006.01) A61P 31/00 (2006.01) C07D 237/14 (2006.01) C07D 239/36 (2006.01) C07D 239/52 (2006.01) C07D 239/54 (2006.01) C07D 241/18 (2006.01) C07D 253/07 (2006.01)

Patent

CA 2745865

Compounds having the formula (I) wherein A, R1, R2, R3, R4a, R4b, R4, R5, R6, R7a, R7b, Ar1, R c, R d, R e, R f, X, n and p are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.

La présente invention concerne des composés de formule (I) dans laquelle A, R1, R2, R3, R4a, R4b, R4c, R5, R6, R7a, R7b, Ar1, Rc, Rd, Re, Rf, X, n et p sont tels que définis dans le présent document, qui sont des inhibiteurs de la polymérase NS5b du virus de l'hépatite C. La présente invention concerne également des compositions et des procédés de traitement d'une infection par le HCV et d'inhibition de la réplication du HCV.

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