Changing th1/th2 balance in split influenza vaccines with...

Details Changing th1/th2 balance in split influenza vaccines with... Changing th1/th2 balance in split influenza vaccines with...

A - Human Necessities

61

K

A61K 39/145 (2006.01) A61K 39/39 (2006.01)

Patent

CA 2628397

The invention seeks to avoid components in split vaccines that could cause an excessive Th2 response. Thus the invention provides an immunogenic composition comprising a split influenza virus antigen and a Th1 adjuvant, wherein the antigen is preferably prepared from a virus grown in cell culture (e.g. it is free from egg proteins).

L'invention vise à éviter des composants dans des vaccins sous-unité susceptibles de provoquer une réponse excessive de Th2. L'invention concerne donc une composition immunogène comprenant un antigène antigrippal sous-unitaire et un adjuvant Th1, l'antigène étant de préférence préparé à partir d'un virus cultivé en culture cellulaire (par exemple, exempt de protéines d'oeufs).

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