Use of oligosaccharides containing n-acetyllactosamine for...

Details Use of oligosaccharides containing n-acetyllactosamine for... Use of oligosaccharides containing n-acetyllactosamine for...

A - Human Necessities

61

K

A61K 31/715 (2006.01) A23L 1/29 (2006.01) A23L 1/308 (2006.01) A61K 31/7016 (2006.01) A61K 31/702 (2006.01) A61P 3/02 (2006.01) A61P 37/04 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2705014

This invention relates to the use of an oligosaccharide selected from the group consisting of lactc -N-tetraose, lacio-N-neotetraose, lacto-N-hexose, lacto-N-neohexaose, para-lacto-N-hexaose, para-lacto-N-neohexaose, lacto-N-octaose, lacto-N-neooctaose, iso- lacto-N-octaose, para- lacto-N-octaose and lacto-N- decaosein the manufacture of a medicament for infants or a therapeutic nutritional composition for infants for modulating immune responses in a neonatal infant. The invention extends to the use of such an oligosaccharide for modulating the immune system of a neonatal infant to promote the development in the first few weeks of the life of the infant of a beneficial intestinal microbiota comparable with that found in breast fed infants and for reducing the risk of subsequent development of allergy in the infant.

Utilisation d'oligosaccharide du groupe comprenant lactc -N-tétraose, lacio-N-neotétraose, lacto-N-hexaose, lacto-N-néohexaose, para-lacto-N-hexaose, para-lacto-N-néohexaose, lacto-N-octaose, lacto-N-néooctaose, iso- lacto-N-octaose, para- lacto-N-octaose et lacto-N-décaose, dans la fabrication de médicament pour nourrissons ou de composition nutritive thérapeutique pour enfants en bas âge permettant de moduler les réponses immunes chez les nouveaux nés. Par ailleurs, utilisation de cet oligosaccharide pour moduler le système immunitaire d'un nouveau né afin de promouvoir le développement de microbiote intestinal bénéfique au cours des premières semaines de vie, comparable avec un développement similaire constaté chez les enfants allaités au sein, et afin de réduire le risque de développement ultérieur d'allergie chez le nourrisson.

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