Controlled release bioactive agent delivery device

Details Controlled release bioactive agent delivery device Controlled release bioactive agent delivery device

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2524271

The invention provides a controlled release bioactive agent delivery device that includes a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension, and a polymeric coated composition in contact with the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent, wherein the first polymer comprises polyalkyl(meth)acrylate, aromatic poly(meth)acrylate, or a combination of polyalkyl(meth)acrylate and aromatic poly(meth)acrylate, and wherein the second polymer comprises poly(ethylene-co-vinyl acetate). The invention also provides the use of said composition for the manufacture of a medicament for delivering a bioactive agent to a patient in a controlled release manner, as well as methods of making a controlled release bioactive agent delivery device.

L'invention concerne un dispositif de relargage d'agent bioactif à libération contrôlée, comprenant : un élément formant corps présentant un sens d'extension, un axe longitudinal s'étendant dans le sens d'extension, une extrémité proximale et une extrémité distale, au moins une partie de l'élément formant corps déviant par rapport au sens d'extension ; et une composition revêtue de polymère, en contact avec l'élément formant corps, ladite composition comprenant un premier polymère, un second polymère et un agent bioactif, le premier polymère comprenant du polyalkyl(méth)acrylate, du poly(méth)acrylate aromatique, ou une combinaison de polyalkyl(méth)acrylate et de poly(méth)acrylate aromatique, et le second polymère comportant du poly(éthylène-co-vinyle acétate). L'invention se rapporte également à des procédés de relargage par libération contrôlée d'un agent bioactif dans un patient, ainsi qu'à des procédés de fabrication d'un dispositif de relargage d'agent bioactif à libération contrôlée.

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