Amino acid diamides in non alpha position useful as...

Details Amino acid diamides in non alpha position useful as... Amino acid diamides in non alpha position useful as...

C - Chemistry, Metallurgy

07

C

C07C 233/83 (2006.01) A61K 47/16 (2006.01) C07C 235/56 (2006.01) C07C 235/64 (2006.01)

Patent

CA 2533639

The invention relates to amino acid diamides in non-a position of formula (1), wherein R1 is selected from amongst the group consisting of functional groups alkyl, halogen, NO2, OH, OCH3 either alone or associated and R2 is selected from the group consisting of functional groups H, alkyl, halogen, NO2, OH, OCH3, which are useful as adjuvants for the administration of active biological agents. The invention also relates to the pharmaceutical compositions containing said diamides of formula (1) and to their use for the production of a medicament for the treatment of a disease selected from amongst the group consisting of inflammation, cancer and allergy.

L'invention concerne des diamides d'aminoacides en position non a représentés par la formule (1), dans laquelle R¿1? est choisi dans le groupe constitué des groupes fonctionnels alkyle, halogéno, NO¿2?, OH, OCH¿3?, seuls ou associés et R¿2? est choisi dans le groupe constitué des groupes fonctionnels H, alkyle, halogéno, NO¿2?, OH, OCH¿3?, ces diamides étant utilisés en tant qu'adjuvants pour l'administration d'agents biologiques actifs. L'invention concerne également des compositions pharmaceutiques qui contiennent ces diamides représentés par la formule (1) et leur utilisation dans la fabrication de médicaments antithrombotiques et dans la fabrication d'un médicament destiné au traitement d'une maladie, notamment l'inflammation, le cancer et l'allergie.

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