Indole derivatives as 5-ht1-like agonists

Details Indole derivatives as 5-ht1-like agonists Indole derivatives as 5-ht1-like agonists

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/395 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07F 1/00 (2006.01) C07F 3/00 (2006.01) C07F 5/02 (2006.01) C07F 7/10 (2006.01) C07F 7/22 (2006.01)

Patent

CA 2117498

A compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein R is phenyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, furyl or thienyl, all of which may be optionally substitued by halo, C1-C4 alkyl, C1-C4 alkoxy or a group of the formula: -X-R2; R1 is H, C1-C6 alkyl, C3-C7 cycloalkyl, C5-C7 cycloalkenyl, C3-C6 alkenyl or C3-C6 alkynyl, said alkyl group being optionally substituted by C3-C7 cycloalkyl, C3-C7 cycloalkyloxy, OH, C1-C6 alkoxy, CONR3R4, SO2NR3R4, COR5, SOR5, SO2R5, CO2R6, aryl, aryloxy, aryl(C1-C6)alkoxy or heteroaryl, said alkenyl group being optionally substituted by aryl and said cycloalkyl group being optionally substituted by OH; the cycloalkyl and cycloalkenyl groups of the foregoing groups being optionally linked to the N-atom by a C1-C2 alkylene moiety; R2 is COR7, CO2R7, SOR7, SO2R7, CONR3R4, SO2NR3R4, NHCOR7, NHCONR3R4, NHSO2R7, NHSO2NR3R4, OH or CN; R3 and R4 are either each independently selected from H, C3-C7 cycloalkyl and C1-C6 alkyl, said alkyl group being optionally substituted by C3-C7 cycloalkyl or aryl, or R3 and R4 taken together represent C3-C6 alkylene optionally interrupted by O, S(O)n, NH or N(C1-C6 alkyl); R5 is C1-C6 alkyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl(C1-C6)alkylene, aryl(C1-C6)alkylene or aryl; R6 is C1-C6 alkyl, C3-C7 cycloalkyl or aryl(C1-C6)alkylene; R7 is C1-C6 alkyl; X is a direct link or C1-C7 alkylene; m is 1 or 2; and n is 0, 1 or 2; are selective 5-HT1-like receptor agonists useful in the treatment of migraine, cluster headache, chronic paroxysmal hemicrania and headache associated with vascular disorders.

Affiliated with

Also associated with

Rating

Indole derivatives as 5-ht1-like agonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Indole derivatives as 5-ht1-like agonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Indole derivatives as 5-ht1-like agonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1544212